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毒性学分野

Laboratory of Toxicology and Safety Science

受賞など

Awards

Awards

2024

  • Anmo Serizawa: KSOT Travel Award for young toxicologists, October 2024.

  • Miyori Takaraku: KSOT Travel Award for young toxicologists, October 2024.

  • Yuma Saeki: Student Poster Presentation Award at the 51st Annual Meeting of the Japanese Society of Toxicology, for the assessment of reproductive toxicity due to silver nanoparticle exposure, July 2024.

  • Wakaba Idehara: Student Poster Presentation Award at the 51st Annual Meeting of the Japanese Society of Toxicology, for research on the intracellular dynamics of micro- and nanoplastics, July 2024.

  • Yuma Saeki: Excellence in Presentation Award at the 144th Annual Meeting of the Pharmaceutical Society of Japan, for evaluating the effects of paternal silver nanoparticle exposure on pregnancy outcomes, April 2024.

2023

  • Kazuma Azuma: Osaka University Award, for research on the impact of particulate exposure on vulnerable generations, October 2023.

  • Junta Kobayashi: Excellence in Presentation Award at the 73rd Annual Meeting of the Kansai Branch of the Pharmaceutical Society of Japan, for evaluating placental permeability and cellular uptake of amorphous nanosilica particles, October 2023.

  • Tetsuhide Nishimura: Excellence in Presentation Award at the 73rd Annual Meeting of the Kansai Branch of the Pharmaceutical Society of Japan, for elucidating survival mechanisms in drug-resistant non-small cell lung cancer cells with a focus on stress response, October 2023.

  • Wakako Okuno: Excellence in Presentation Award at the 73rd Annual Meeting of the Kansai Branch of the Pharmaceutical Society of Japan, for evaluating the effects of valproic acid on forskolin-induced BeWo cell syncytialization, October 2023.

  • Sota Manabe: Student Poster Presentation Award at the 50th Annual Meeting of the Japanese Society of Toxicology, for findings that UV-degraded microplastics induce autophagy-dependent cell death, June 2023.

  • Rena Yamamoto: Young Scientist Excellence in Presentation Award at the 29th Annual Meeting of the Japan Society for Food Chemistry, for analysis of placental inflammation response to amorphous nanosilica exposure, June 2023.

  • Natsuko Kitamoto: JSOT ASIATOX-X Travel Award, for investigation of benzopyrene-induced cellular senescence mechanisms in breast cancer, May 2023.

  • Sota Manabe: JSOT ASIATOX-X Travel Award, for research on autophagy-dependent cytotoxicity mechanisms caused by degraded microplastics, May 2023.

  • Natsuko Kitamoto: Excellence in Presentation Award at the 143rd Annual Meeting of the Pharmaceutical Society of Japan, for elucidating the molecular mechanisms of benzopyrene-induced cellular senescence in malignant transformation of breast cancer, April 2023.

  • Ryono Tanahashi: Excellence in Presentation Award at the 143rd Annual Meeting of the Pharmaceutical Society of Japan, for uncovering immune evasion mechanisms and characteristics of chemotherapy-resistant cancer cells, April 2023.

  • Sota Manabe: Excellence in Presentation Award at the 143rd Annual Meeting of the Pharmaceutical Society of Japan, for elucidating cytotoxicity mechanisms of surface-degraded microplastics, April 2023.

2022

  • Professor Yasuo Tsutsumi: Toyama Tsubakiyoshi Memorial Science Award from the Tokyo Micrograph Foundation, for research on next-generation impacts and safety evaluation of nanomaterials in food, January 2023.

  • Tsuyoshi Kitahara: Excellence in Presentation Award at the 72nd Annual Meeting of the Kansai Branch of the Pharmaceutical Society of Japan, for elucidating valproic acid's disruption mechanisms on placental hormones, October 2022.

  • Hiroto Konishi: Excellence in Presentation Award at the 72nd Annual Meeting of the Kansai Branch of the Pharmaceutical Society of Japan, for studying antitumor effects during ferroptosis induction targeting tumor-associated macrophages, October 2022.

  • Yudai Ikuno: Student Poster Presentation Award at the 49th Annual Meeting of the Japanese Society of Toxicology, for evaluating the cytotoxicity of environmental microplastics considering their degradation state, July 2022.

  • Yuji Sakahashi: Excellence in Presentation Award at the 142nd Annual Meeting of the Pharmaceutical Society of Japan, for investigating the role of reactive oxygen species in inhibiting placental cell syncytialization induced by silver nanoparticles, April 2022.

  • Yuki Tsuji: Excellence in Presentation Award at the 142nd Annual Meeting of the Pharmaceutical Society of Japan, for elucidating the role of GABA metabolic enzymes in liver cancer, April 2022.

2021

  • Kazuma Higashisaka: 2022 Japan Pharmaceutical Society Encouragement Award, Health Impact Assessment and Safety Assurance of Nanoparticles Based on Analysis of the Correlation Between Physical Properties, Dynamics, and Toxicity for Vulnerable Generations, March 2022.

  • Yuya Haga: 2021 Japan Pharmaceutical Society Kansai Branch Encouragement Award, Analysis of Reversible Drug-Resistant Cells in Non-Small Cell Lung Cancer, December 2021.

  • Yuya Haga: Excellent Presentation Award at the 141st Annual Meeting of the Japan Pharmaceutical Society, Elucidation of the Mechanism of Early Resistance to Dasatinib in Triple Negative Breast Cancer, April 2021.

  • Shintaro Yamaguchi: Excellent Presentation Award at the 141st Annual Meeting of the Japan Pharmaceutical Society, Evaluation of the Impact of Silver Nanoparticles on Neuronal Cell Differentiation, April 2021.

  • Yudai Ikuno: Excellent Presentation Award at the 18th Physical Pharma Forum for the Next Generation, Establishment of a Foundation for Evaluating Biological Effects of Microplastics in Real Environments, September 2021.

  • Yurie Tada: Excellent Presentation Award at the 18th Physical Pharma Forum for the Next Generation, Construction of a CYP Reductase Mutant Library Aiming to Elucidate the Electron Transfer Mechanism, September 2021.

2020

  • Shunichi Eto: Student Poster Presentation Award at the 47th Annual Meeting of the Japanese Society of Toxicology, Hazard Identification of Amorphous Nanoparticles Mediated by Acquired Immunity and Correlation Analysis with Physical Properties, July 2020.

  • Yuji Sakahashi: Student Poster Presentation Award at the 47th Annual Meeting of the Japanese Society of Toxicology, Analysis of the Effect of Silver Nanoparticles on Forskolin-Induced BeWo Cell Syncytialization, July 2020.

2019

  • Jing Kai Chen: Selected for the 2019 Maruho Graduate Student Overseas Dispatch Program, April 2019.

  • Ryo Isaka: Excellent Presentation Award at the 13th Symposium on Next Generation Young Medical Pharmaceutical Science, Evaluation of the Role of an Integrin Ligand in the Epithelial-Mesenchymal Transition of Proximal Tubule Cells, October 2019.

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2018

  • Shunichi Eto: Young Researcher Excellent Presentation Award at the 25th Annual Meeting of the Japanese Society of Immunotoxicology, Acquired Immunity-Mediated Exacerbation of Liver Injury Induced by Amorphous Nanoparticles due to Prior Exposure, September 2018.

  • Mori Shunichi: Poster Presentation Award at the 68th Annual Meeting of the Kansai Branch of the Japan Pharmaceutical Society, Drug Binding Evaluation of Cytochrome P450 Using Lipid Nanodisc Complexes, October 2018.

  • Shunichi Eto and Jing Kai Chen: Selected for the "Student Member ICT XV 2019 Hawaii Participation Support Program" by the Japanese Society of Toxicology, February 2019.

  • Shunichi Eto: Excellent Presentation Award (Oral Presentation) at the 139th Annual Meeting of the Japan Pharmaceutical Society, Cellular Immunity Exacerbates Liver Injury Induced by Amorphous Nanoparticles, March 2019.

  • Maito Toyoda: Excellent Presentation Award (Poster Presentation) at the 139th Annual Meeting of the Japan Pharmaceutical Society, Evaluation of Expression Changes and Function of Cytoskeletal Proteins in Heart Failure Pathophysiology, March 2019.

  • Kohei Izumisawa: Excellent Presentation Award (Poster Presentation) at the 139th Annual Meeting of the Japan Pharmaceutical Society, Study on the Mechanism of EGFR-TKI Resistance in Non-Small Cell Lung Cancer Focused on Cytochrome P450, March 2019.

2017

  • Shunichi Eto: Excellent Presentation Award at the 138th Annual Meeting of the Japan Pharmaceutical Society, Study Towards Identifying Factors Related to the Exacerbation of Liver Injury Due to Prior Administration of Amorphous Nanoparticles, March 2018.

2016

  • Kazuya Nagano: Japan Pharmaceutical Society Encouragement Award, November 2016.

  • Junpei Kasahara: Faculty of Pharmaceutical Sciences Award, March 2017.

  • Mariko Takeda: Excellent Presentation Award at the 137th Annual Meeting of the Japan Pharmaceutical Society, Evaluation of Absorption of Amorphous Curcumin Aiming at the Development of High-Quality Functional Foods, March 2017.

  • Yuya Haga: Excellent Presentation Award at the 137th Annual Meeting of the Japan Pharmaceutical Society, Study Towards Elucidating the Molecular Pathology of Triple Negative Breast Cancer Using Breast Cancer Cells, March 2017.

2015

  • Michihiko Aoyama: Best Presentation Award at the 14th Forum for Young Pharma-Bio for Next Generation 2015, Quantitative Analysis of Intracellular Motion Towards Elucidating the Dynamics of Nanomaterials, September 2015.

  • Sonoko Taketani: Excellent Presentation Award at the 136th Annual Meeting of the Japan Pharmaceutical Society, Fundamental Study Towards Evaluating Biological Effects by Enhancing Antibody Affinity, March 2016.

2014

  • Hiroki Morishita: Excellent Presentation Award at the 13th Forum for Young Pharma-Bio for Next Generation 2014, Evaluation of Nanomaterials' Transferability in Breast Milk and Their Effects on Offspring, October 2014.

  • Toshiro Hirai: Best Presentation Award at the 13th Forum for Young Pharma-Bio for Next Generation 2014, Importance of Metallic Nanoparticles in the Development of Metal Allergies, October 2014.

  • Toshiro Hirai: Student/Young Researcher Excellent Presentation Award at the 21st Annual Meeting of the Japanese Society of Immunotoxicology, Role of Nanoparticles in the Development of Metal Allergies, September 2014.

  • Yasuo Tsutsumi: 3rd Osaka University President's Award (Research Division), August 2014.

  • Yasuo Yoshioka: 3rd Osaka University President's Encouragement Award (Research Division), August 2014.

  • Michihiko Aoyama: Young Researcher Excellent Presentation Award at the 30th Annual Meeting of the Japan DDS Society, Basic Analysis Towards Understanding the Intracellular Behavior of Nanomaterials, July 2014.

2013

  • Toshiro Hirai: Student Excellent Presentation Award at the 134th Annual Meeting of the Japan Pharmaceutical Society, Co-skin Exposure to Nanoparticles and Allergens Promotes IgE-Mediated Sensitization via IgG Suppression, March 2013.

  • Kazuma Higashisaka: Encouragement Award at the 63rd Annual Meeting of the Kansai Branch of the Japan Pharmaceutical Society, Analysis of the Impact of Nanomaterials as New Pharmaceutical Materials on Biological Defense Mechanisms, December 2013.

  • Yasuo Tsutsumi: 10th Japan Society for the Promotion of Science Award, December 2013.

  • Toshiro Hirai: Excellent Presentation Award at the 60th Kinki Branch Meeting of the Japan Biochemical Society, Biological Response to Fine Particles 2: Promotion of Transdermal Allergic Sensitization by Amorphous Nanoparticles, May 2013.

  • Toshiro Hirai: Excellent Research Presentation Award at the 40th Annual Meeting of the Japanese Society of Toxicology, Interaction of Nanoparticles with Antigens Promotes Unknown Allergic Reactions via Transdermal Exposure, June 2013.

  • Yasuo Tsutsumi: 2nd Osaka University President's Award (Research Division), August 2013.

  • Yasuo Yoshioka: 2nd Osaka University President's Encouragement Award (Research Division), August 2013.

  • Kazuma Higashisaka: 2nd International Conference on Translational and Personalized Medicine - Best Poster Award, Fullerenol C60 as a New Therapeutic Nanomedicine for Inflammatory Bowel Disease, August 2013.

  • Yasuo Yoshioka: 20th Annual Meeting of the Japanese Society of Immunotoxicology - Encouragement Award, Evaluation of the Immunotoxicity of Fine Particles Contributing to Ensuring the Safety of Nanomaterials, September 2013.

2012

  • Toshiro Hirai: Student/Young Researcher Excellent Presentation Award at the 19th Annual Meeting of the Japanese Society of Immunotoxicology, Immunotoxicity Evaluation Towards the Creation of Safe Nanomaterials: New Immunological Effects Induced by Amorphous Nanoparticles, September 2012.

  • Kazuma Higashisaka: Best Poster Award at the International Congress on Safety of Engineered Nanoparticles and Nanotechnologies (SENN2012), Association Between Neutrophilia and Inflammatory Responses for Ensuring Safety of Nanomaterials, October 2012.

  • Yuka Maeda: Young Researcher Encouragement Award from the Pharmacy Friends Association, Evaluation of the Utility of Novel Breast Cancer-Related Protein (Eph Receptor A10) as a Drug Discovery Target, March

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2012.

  • Kota Tanaka: Faculty of Pharmaceutical Sciences Award/Kusumoto Prize, March 2012.

  • Hiroki Morishita: Excellent Presentation Award at the 133rd Annual Meeting of the Japan Pharmaceutical Society, Evaluation of the Impact of Subnanomaterials on Fetuses Contributing to Nano-Safety Science, March 2012.

  • Hideki Takahashi: Excellent Presentation Award at the 133rd Annual Meeting of the Japan Pharmaceutical Society, Importance of Nano-Safety Science Research on Nanomaterials Considering Mouse Strains, March 2012.

  • Koichi Ichihashi: Excellent Presentation Award at the 133rd Annual Meeting of the Japan Pharmaceutical Society, Proposal for the Importance of Evaluating Transdermal Safety Through Comparative Analysis of the Absorption and General Toxicity of Nano Silver and Subnano Silver, March 2012.

  • Nobuaki Mori: Excellent Presentation Award at the 133rd Annual Meeting of the Japan Pharmaceutical Society

  • 2011

  • Miyuki Uji: Award for Outstanding Student Presentation at the 132nd Annual Meeting of the Pharmaceutical Society of Japan, Fundamental Study on the Nephrotoxicity Induced by Orally Administered Sub-Nanoplatinum, March 2012.

  • Kenmasa Ogura: Award for Outstanding Student Presentation at the 132nd Annual Meeting of the Pharmaceutical Society of Japan, Fundamental Study Towards Correlational Analysis of Surface Properties and Developmental Toxicity of Amorphous Nano-Silica, March 2012.

2010

  • Tomoa Yoshikawa: Outstanding Research Presentation Award at the 37th Annual Meeting of the Japanese Society of Toxicology, Towards Ensuring the Safety of Nanomaterials: Accumulation of Basic Information on the Intracellular Localization and Safety of Amorphous Nano-Silica, June 2010.

  • Shuhei Arita: JSI Young Investigators’ Travel Award for 14th ICI, Characterization of Interleukin-1 Family Cytokines as an Adjuvant for Mucosal Vaccine Against Influenza Virus, August 2010.

  • Takuya Yamashita: HUPO 2010 Proteomics Idol, Search for Metastasis-Related Biomarker Proteins in Colorectal Cancer by Proteomics and Tissue Microarray Analysis, September 2010.

2009

  • Akira Onodera: Outstanding Presentation Award at the 36th Annual Meeting of the Japanese Society of Toxicology, Development of a Simple Analysis Method for New Mitochondrial DNA Damage, July 2009.

  • Hiroyuki Kayamuro: Melchers’ Travel Award at the 39th Annual Meeting of the Japanese Society of Immunology, Characterization of Mucosal and Systemic Immune Responses Elicited by Interleukin Cytokines as Mucosal Vaccine Adjuvant Against Influenza Virus, December 2009.

  • Shuhei Arita: Outstanding Presenter Award at the PharmaBio Forum, Development of Cytokine Adjuvants for Nasal Influenza Vaccines, November 2009.

2008

  • Hiroyuki Kayamuro: Outstanding Presenter Award at the PharmaBio Forum, Application of Activating Mutant TNF Variants as Mucosal Vaccine Adjuvants, November 2008.

  • Hiroyuki Kayamuro: 12th International TNF Conference ANRF Travel Award, Identification of New Candidates as Mucosal Vaccine Adjuvants in TNF Superfamily Cytokines, March 2009.

Japan Society for the Promotion of Science Special Research Fellows

  • Takashi Nagano (H26~): Japan Society for the Promotion of Science Special Research Fellow DC2, Creation of Artificial Peptides with Excellent Pharmaceutical Value and Development for Treatment of Bone Metabolic Diseases.

  • Michihiko Aoyama (H26~): Japan Society for the Promotion of Science Special Research Fellow DC1, Design of "Intracellular Drug Delivery Nanocarriers" Aimed at Organelle Targeting.

  • Hiroki Morishita (H25~): Japan Society for the Promotion of Science Special Research Fellow DC2, Development of New Nanodrug Delivery Systems Aimed at Establishing Placenta-Targeting Therapy.

  • Hideki Takahashi (H25~): Japan Society for the Promotion of Science Special Research Fellow DC1, Design of New Transdermal Nanocarriers Aimed at Overcoming Vaccine Hazards.

  • Kazuki Misato (H25~): Japan Society for the Promotion of Science Special Research Fellow DC1, Research on Nano-Safety Science Contributing to the Creation of Safe Food Nanomaterials.

  • Nobuyuki Yoshida (H24~): Japan Society for the Promotion of Science Special Research Fellow DC2, Development of Safety Evaluation Methods for Chemical Substances in Foods Based on Qualitative and Quantitative Changes in Intestinal Bacteria.

  • Kazuma Higashiosaka (H24~): Japan Society for the Promotion of Science Special Research Fellow DC2, Exploration of Safety Evaluation Markers of Nanomaterials Contributing to the Design of Effective and Safe Nanomedicines.

  • Toshiro Hirai (H24~): Japan Society for the Promotion of Science Special Research Fellow DC1, Development of Biological Modification Techniques for Nanomaterials Contributing to the Efficiency of Nanomedicine Development.

  • Kohei Yamashita (H23~): Japan Society for the Promotion of Science Special Research Fellow DC2, Creation of Non-Invasive Nano DDS Medicines Using Fullerene and Application to Inflammatory Bowel Disease Treatment.

  • Hiromi Nabeshima (H20~): Japan Society for the Promotion of Science Special Research Fellow DC2, Elucidation of APL Therapeutic Mechanisms Based on Oxidative Modifications and Identification of Efficacy Prediction Markers.

その他

**FY 2016**  
- Research findings on a new mechanism for the manifestation of metal allergy were published in *Nature Nanotechnology*.  

- Research findings on the transfer of nanoparticles through breast milk were published in *ACS NANO*.  
 

**FY 2015**  
- Ryo Ishimoto, Yuki Namba, Natsumi Izumi, Yuki Shimizu, and Ayaka Maki were selected for the 1st Doctoral Student Overseas Dispatch Support Project (President’s Leadership).  
- Professors Yasuo Tsutsumi, Kazuya Nagano, and Kazuma Higashisaka were invited to and participated in the 1st Exchange Symposium held at Zhejiang University.  
- Professor Yasuo Tsutsumi organized the following symposium at the 136th Annual Meeting of the Pharmaceutical Society of Japan.  
  - Title: Latest Trends in Safety Evaluation for the Social Acceptance of Nanomaterials  
  - Chairs: Yasuo Tsutsumi, Akihiko Hirose  

 

**FY 2014**  
- "Innovation from Life Sciences to Drug Discovery" (Nankodo), co-edited by Professor Yasuo Tsutsumi, was published.  

 

**FY 2013**  
- Professor Yasuo Tsutsumi was selected as the *Journal of Pharmaceutical Sciences (JPharmSci)* 2013 Top Reviewer.  
- Professor Tsutsumi participated in the antibody screening project at the Drug Discovery Support Center of the National Institute of Biomedical Innovation.  

 

**FY 2012**  
- Professor Yasuo Tsutsumi was selected as the *Journal of Pharmaceutical Sciences (JPharmSci)* 2012 Top Reviewer.  
- Findings on safety evaluation research for nanomaterials were published in the February 6, 2012 evening edition of the *Asahi Shimbun* on page 9 (Kansai edition) and on page 1 (Kanto edition).  
- Articles on nanomaterials and safety evaluations were published in the special issue of *Yakuji Nippo* (March 21, 2012, 132nd Annual Meeting of the Pharmaceutical Society of Japan).  

 

**FY 2011**  
- Research findings on safety evaluation of nanomaterials were published in *Chemical & Engineering News* (April 11, 2011, Vol. 89, No. 15, P35) and the April 25 edition of *Nihon Keizai Shimbun*, page 11.  
- Studies on the reproductive and developmental toxicity of nanomaterials (Nat. Nanotechnol., 6(5):321-328, 2011) were featured in the *News and Views* section of *Nature Nanotechnology*.  
- The 2011 Osaka University Graduate School of Pharmaceutical Sciences Public Lecture Series was planned and organized by Tsutsumi and Yoshioka.

 

**FY 2010**  
- Findings from antibody proteomics research (identifying EphA10) were featured in the September 6, 2010 edition of the *Nihon Keizai Shimbun*, page 11.  
- Research on the TNF-TNFR2 complex structure was featured on the cover of *Science Signaling* (Vol. 3, Issue 148, 2010).  
- *Journal of Pharmaceutical Sciences* selected Professor Tsutsumi as a Top Reviewer for 2010.

**FY 2009**  
- The research results of the Toxicology Division's Nanotoxicology study were published in *Nature* (Vol. 461, 2009).  
- A symposium organized by Tsutsumi and Yoshioka at the 130th Annual Meeting of the Pharmaceutical Society of Japan was highlighted.

**FY 2008**  
- At the 128th Annual Meeting of the Pharmaceutical Society of Japan, Tsutsumi and Kakuta organized a symposium on the application and risks of nanomaterials in pharmaceuticals.

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