堤 康央 Tsutsumi Yasuo
長野 一也 Nagano Kazuya
(応用環境生物学分野)
辻野 博文 Tsujino Hirofumi
(総合学術博物館)
原田 和生 Harada Kazuo
(医学系研究科)
東阪 和馬 Higashisaka Kazuma
(医学系研究科)
毒性学分野
Laboratory of Toxicology and Safety Science
マイクロ・ナノプラスチックの安全性評価
Safety Assessment of Micro- and Nanoplastics
Negative biological effects caused by microplastics (MPs; plastic particles less than 5 mm) and even smaller nanoplastics (NPs; plastic particles less than 1 μm) in the environment are a growing concern. These MPs and NPs have already been detected in the human body (such as in the lungs, placenta, and blood), indicating that we cannot avoid exposure, making the analysis of risks (hazard × exposure situation and dynamics) an urgent challenge.
On the other hand, it is known that MPs and NPs are complex systems with various types and diverse physicochemical properties (physical characteristics such as size, shape, and surface chemical modifications due to UV exposure). The hazards and dynamics of MPs and NPs are determined by their forms of existence (types and their physical properties), necessitating the consideration of real environments during risk analysis. However, there are currently no standard materials for MPs and NPs that meet the requirements for such research, both domestically and internationally.
To address this, the field of toxicology is developing standard materials for MPs and NPs that reflect the complex forms of existence in the environment as a library. Through dynamic and various hazard analyses, we aim to promote an integrated safety assessment of MPs and NPs. We plan to distribute these materials through collaborative research both domestically and internationally. For more details, please feel free to contact us.
Overview
About polymer types ・PE (Polyethylene) ・PP (Polypropylene) ・PS (Polystyrene) ・PET (Polyethylene Terephthalate) ・PVC (Polyvinyl Chloride)
About size ・Ranging from 100 nm to 10 µm or more.
About shape ・Spherical ・Fragment ・Fiber
About surface ・Non-oxidized ・Oxidized with VUV exposure
Related Publications
・Manabe S., Haga Y., Tsujino H., Ikuno Y., Asahara H., Higashisaka K., Tsutsumi Y. : Treatment of polyethylene microplastics degraded by ultraviolet light irradiation causes lysosome-deregulated cell death., Sci. Rep., 14(1):24008., 2024. ・Ikuno Y., Tsujino H., Haga Y., Manabe S., Idehara W., Hokaku M., Asahara H., Higashisaka K., Tsutsumi Y. : Polyethylene, whose surface has been modified by UV irradiation, induces cytotoxicity: A comparison with microplastics found in beaches., Ecotoxicol. Environ. Saf., 277: 116346, 2024. ・Ikuno Y., Tsujino H., Haga Y., Asahara H., Higashisaka K., Tsutsumi Y. : Impact of degradation of polyethylene particles on their cytotoxicity., Microplastics, 2(2): 192-201, 2023. [Pubmed]