堤 康央 Tsutsumi Yasuo
長野 一也 Nagano Kazuya
(応用環境生物学分野)
辻野 博文 Tsujino Hirofumi
(総合学術博物館)
原田 和生 Harada Kazuo
(医学系研究科)
東阪 和馬 Higashisaka Kazuma
(医学系研究科)
毒性学分野
Laboratory of Toxicology and Safety Science
研究内容
Research
In pharmaceutical science aimed at securing human health, “Toxicology and Safety Science” is a discipline that addresses not only conventional medicines but also cutting-edge pharmaceuticals such as biopharmaceuticals utilizing genes, proteins, and cells, as well as nanomedicines based on nanotechnology. Additionally, it examines the safety of quasi-drugs, cosmetics, food products, and the environment (ecosystems), all with the goal of establishing a "safe and secure health environment" and cultivating skilled personnel to lead this field. Therefore, society has come to expect the field of "Toxicology in Pharmaceutical Sciences," also known as Safety Science, to:
1. elucidate adverse events (toxicity mechanisms) arising from various environmental chemicals like microplastics and modern medicines such as vaccines, antibodies, and nanomedicines, from a safety assessment perspective,
2. scientifically support the development of safe pharmaceuticals, cosmetics, and foods, thereby promoting social acceptance through risk communication and literacy to ensure both safety and public confidence,
3. evaluate impacts on human health and the environment (ecosystems) based on scientific evidence to secure safety, especially for exposures that are unavoidable, intentional or unintentional, and
4. develop or support effective detoxification, treatments, and preventive methods against drug and environmental hazards.
Amidst the rising global spread of emerging and re-emerging infectious diseases, increasing concerns about drugs, food, and the environment, and growing public interest in health, products of 21st-century technology face unprecedented demands for safety and reliability, further accelerating expectations for the field of toxicology.
With this perspective, the field of toxicology promotes safety assessment research on nanomaterials and other chemicals (exposure, kinetics, and hazard assessment), as well as the development of foundational technologies to ensure safety. Our research uses analytical chemistry techniques, including genetic engineering, protein/antibody engineering, and omics analysis, to explore the toxicity mechanisms (disease onset and exacerbation) of various environmental chemicals, the body's intrinsic defense mechanisms, and to develop detoxification methods (therapies and therapeutic agents).
Our research project is situated within a multidisciplinary area that encompasses toxicology, kinetics, analytical chemistry, physical chemistry, biochemistry, immunology, and more. This field provides a foundation for fostering creativity and a research approach grounded in extensive knowledge from this interdisciplinary domain, with the objective of nurturing researchers who can independently carry out research from various perspectives. Our laboratory welcomes all students interested in this field to visit our laboratory.
Research Topics:
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Reproductive toxicity and developmental toxicity of chemical substances
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Toxico-kinetics analysis and control of exogenous particle
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Development of fundamental technology and drug discovery for elucidating the molecular pathology of malignant tumors
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Genotoxicity, carcinogenicity and immunotoxicity of micro/nanoplastics and development of detoxification methods