堤 康央 Tsutsumi Yasuo
長野 一也 Nagano Kazuya
（応用環境生物学分野）
辻野 博文 Tsujino Hirofumi
（総合学術博物館）
原田 和生 Harada Kazuo
（医学系研究科）
東阪 和馬 Higashisaka Kazuma
（医学系研究科）
毒性学分野
Laboratory of Toxicology and Safety Science
2024
Manabe S., Haga Y., Tsujino H., Ikuno Y., Asahara H., Higashisaka K., Tsutsumi Y. : Treatment of polyethylene microplastics degraded by ultraviolet light irradiation causes lysosome-deregulated cell death., Sci. Rep., in press.
Saeki Y., Higashisaka K., Izutani R., Seo J., Miyaji K., Haga Y., Tsutsumi Y. : Orally administered silver nanoparticles are absorbed and migrate to the testes in mice., ACS Nanosci. Au, 2024.
Simoni-Nieves A., Lindzen M., Giri S., Gupta N., Chatterjee R., Selvadurai B.-R., Van Daele M., Love D., Haga Y., Romaniello D., Salame T.-M., Zerbib M., Oren R., Tsutsumi Y., Lauriola M., Marrocco I., Yarden Y.: A bispecific antibody targeting EGFR and AXL delays resistance to osimertinib, Cell Rep Med., 17;5(9):101703., 2024.
[Pubmed]
Kobayashi J., Higashisaka K., Muranaka M., Xie Y., Okuno W., Haga Y., Tsutsumi Y. : Localization of silica nanoparticles to lysosome causes lysosomal dysfunction in JEG-3 cell., Biochem. Biophys. Res. Commun., 736: 150488, 2024.
[Pubmed]
Ikuno Y., Tsujino H., Haga Y., Manabe S., Idehara W., Hokaku M., Asahara H., Higashisaka K., Tsutsumi Y. : Polyethylene, whose surface has been modified by UV irradiation, induces cytotoxicity: A comparison with microplastics found in beaches., Ecotoxicol. Environ. Saf., 2024.
[Pubmed]
Kitahara G., Higashisaka K., Nakamoto Y., Yamamoto R, Okuno W., Serizawa M., Sakahashi Y., Tsujino H., Haga Y., Tsutsumi Y. : Valproic acid induces HIF-1α-mediated CGB expression elevation and glucose uptake suppression in BeWo cell., J. Toxicol. Sci., 2024.
Konishi H., Haga Y., Okumura M., Tsujino H., Higashisaka K., Tsutsumi Y. : Coculture with macrophages alters ferroptosis susceptibility of triple-negative cancer cells., Cell Death Discov., 2024.
[Pubmed]
Nagano K., Nakao T., Takeda M., Hirai H., Maekita H., Nakamura M., Imakawa N., Egawa A., Fujiwara T., Gao JQ., Kinoshita K., Sakata M., Nishino M., Yamashita T., Yoshida T., Harada K., Tachibana K., Doi T., Hirata K., Tsujino H., Higashisaka K., Tsutsumi Y. : Polyglycerol fatty acid ester contributes to the improvement and maintenance of water solubility of amorphous curcumin by suppressing the intermolecular interaction and the diffusion rate of curcumin., Food Chem., 2024.
Hagihara H., Shoji H., Hattori S., Sala G., Takamiya Y., Tanaka M., Ihara M., Shibutani M., Hatada I., Hori K., Hoshino M., Nakao A., Mori Y., Okabe S., Matsushita M., Urbach A., Katayama Y., Matsumoto A., Nakayama IK., Katori S., Sato T., Iwasato T., Nakamura H., Goshima Y., Raveau M., Tatsukawa T., Yamakawa K., Takahashi N., Kasai H., Inazawa J., Nobuhisa I., Kagawa T., Taga T., Darwish M., Nishizono H., Takao K., Sapkota K., Nakazawa K., Takagi T., Fujisawa H., Sugimura Y., Yamanishi K., Rajagopal L., Hannah DN., Meltzer YH., Yamamoto T., Wakatsuki S., Araki T., Tabuchi K., Numakawa T., Kunugi H., Huang LF., Hayata-Takano A., Hashimoto H., Tamada K., Takumi T., Kasahara T., Kato T., Graef AI., Crabtree RG., Asaoka N., Hatakama H., Kaneko S., Kohno T., Hattori M., Hoshiba Y., Miyake R., Obi-Nagata K., Hayashi-Takagi A., Becker JL., Yalcin I., Hagino Y., Kotajima-Murakami H., Moriya Y., Ikeda K., Kim H., Kaang BK., Otabi H., Yoshida Y., Toyoda A., Komiyama HN., Grant GNS., Ida-Eto M., Narita M., Matsumoto K., Okuda-Ashitaka E., Ohmori I., Shimada T., Yamagata K., Ageta H., Tsuchida K., Inokuchi K., Sassa T., Kihara A., Fukasawa M., Usuda N., Katano T., Tanaka T., Yoshihara Y., Igarashi M., Hayashi T., Ishikawa K., Yamamoto S., Nishimura N., Nakada K., Hirotsune S., Egawa K., Higashisaka K., Tsutsumi Y., Nishihara S., Sugo N., Yagi T., UenoN., Yamamoto T., Kubo Y., Ohashi R., Shiina N., Shimizu K., Higo-Yamamoto S., Oishi K., Mori H., Furuse T., Tamura M., Shirakawa H., Sato XD., Inoue UY., Inoue T., Komine Y., Yamamori T., Sakimura K., Miyakawa T. : Large-scale animal model study uncovers altered brain pH and lactate as a transdiagnostic phenotype of disorders with cognitive defects., Elife, 2024.
[Pubmed]
2023
Marrocco I., Giri S., Simoni-Nieves A., Gupta N., Rudnitsky A., Haga Y., Romaniello D., Sekar A., Zarbib M., Oren R., Lindzen M., Fard D., Tsutsumi Y., Lauriola M., Tamagnone L., Yarden Y. : L858R emerges as a potential biomarker predicting response of lung cancer models to anti-EGFR antibodies: head-to-head comparison of osimertinib versus cetuximab., Cell Rep Med., 2023.
[Pubmed]
Ikuno Y., Tsujino H., Haga Y., Asahara H., Higashisaka K., Tsutsumi Y. : Impact of degradation of polyethylene particles on their cytotoxicity., Microplastics, 2023.
Martin, Watanabe R., Hashimoto K., Higashisaka K., Haga Y., Tsutsumi Y., Mizuguchi K.: Evidence-Based Prediction of Cellular Toxicity for Amorphous Silica Nanoparticles, ACS Nano, 2023.
[Pubmed]
Ramon FA., Wada Y., Ishii H., Watakabe Y., Tsutsumi M., Jang K., Otomo K., Qiao L., Fujii Y., Tsujino H., Tsutsumi Y., Nemoto T., Arisawa M. : Absorption, fluorescence, and two-photon excitation ability of 5-phenyl-13-arylisoindolo [2,1-α] quinolines prepared by one-pot reaction of ring-closing metathesis and 1,3-dipolar cycloaddition., Dyes Pigm., in press.
Yang L., Haga Y., Nishimura A., Tsujii Y., Tanahashi S., Tsujino H., Higashisaka K., Tsutsumi Y. : Chemotherapy aggravates cell migration of triple negative breast cancer cell lines mediated by alpha-crystallin B chain., Sci. Rep., 2023.
[Pubmed]
2022
Sakahashi Y., Higashisaka K., Isaka R., Izutani R., Seo J., Furuta A., Yamaki-Ushijima A., Tsujino H., Haga Y., Nakashima A., Tsutsumi Y. : Silver nanoparticles suppressed forskolin-induced syncytialization in BeWo cells., Nanotoxicology, [PubMed]
Sakahashi Y., Yamamoto R., Kitahara G., Izutani R., Tsujino H., Haga Y., Higashisaka K., Tsutsumi Y. : Amorphas silica nanoparticles decrease human chorionic gonadotropin β expression during syncytialization of BeWo cell., BPB Reports, 2022.
Yamaguchi S., Isaka R., Sakahashi Y., Tsujino H., Haga Y., Higashisaka K., Tsutsumi Y. : Silver Nanoparticles Suppress Retinoic Acid–induced Neuronal Differentiation in Human-derived Neuroblastoma SH-SY5Y Cells., ACS Appl Nano Mater., in press.
Konishi H., Haga Y., Lin Y., Tsujino H., Higashisaka K., Tsutsumi Y. : Osimertinib-tolerant lung cancer cells are susceptible to ferroptosis., Biochem. Biophys. Res. Commun., [PubMed]
2021
Eto S., Higashisaka K., Koshida A., Sato K., Ogura M., Sakurai M., Tsujino H., Nagano K., Tsutsumi Y. : Amorphous silica nanoparticles exacerbate hepatic damage through the activation of acquired cell-mediated immunity., Nano Ex., 2022.
Nakajima T., Nagano K.,Fukuda Y., Ishima Y., Shibata H., Isaka R., Zhang T., Haga Y., Higashisaka K., Tsujino H., Ishida T., Ishii-Watabe A., Tsutsumi Y. : Subvisible particles derived by dropping stress enhance anti-PEG antibody production and clearance of PEGylated proteins in mice., J Pharm Sci., 2022.
[PubMed]
Higashisaka K., Takeya S., Kamada H., Obana M., Maeda M., Kabayama M., Yamamoto K., Ishida N., Isaka R., Tsujino H., Nagano K., Tomiyama N., Rakugi H., Fujio Y., Kamide K., Tsutsumi Y.: Identification of biomarkers of chronic kidney disease among kidney-derived proteins, Clinical Proteomics, 2022.
[PubMed]
Eto S., Koshida A., Tsujino H., Nagano K., Higashisaka K., Tsutsumi Y.: Silica particles with human protein corona shows sensitization potential in the human cell line activation test, BPB reports, 2022.
Yang L., Higashisaka K., Shimoda M., Haga Y., Sekine N., Tsujino H., Nagano K., Shimazu K., Tsutsumi Y. : Alpha-crystallin B chains in trastuzumab-resistant breast cancer cells promote endothelial cell tube formation through activating mTOR., Biochem. Biophys. Res. Commun., 2021.
[PubMed]
Yang L., Higashisaka K., Haga Y., Tsujino H., Nagano K., Tsutsumi Y. : Alpha-crystallin B chains enhance cell migration in basal-like 2 triple-negative breast cancer cells., Pharmazie, 2022.
[PubMed]
Isaka R., Ishida N., Kitahara G., Sakahashi Y., Haga Y., Tsujino H., Nagano K., Higashisaka K., Tsutsumi Y. : Indoxyl sulfate induces an inflammatory response in the proximal tubule via macrophages., BPB Reports, 2021.
Wada Y., Takehara T., Suzuki T., AOKI S., Hibi T., Sako M., Tsujino H., Tsutsumi Y., Arisawa M. : Carbon-Carbon Bond Formation Between Nitrogen-Containing Heterocyclic Carbene (NHC) Ligand on Ruthenium Carbene Catalysts and 1,4-Naphthoquinone via Intramo-lecular Carbon-Hydrogen Bond Activation., Organometallics., 2021.
Hanamuro S., Lin Y., Konishi H., Izusawa K., Yang L., Haga Y., Tsujino H., Nagano K., Higashisaka K., Tsutsumi Y.,: Progesterone receptor membrane component 2 expression leads to erlotinib resistance in lung adenocarcinoma cells, Pharmazie, 2021.
[PubMed]
Ulibe M L., Dahlhoff M, Batra R N., Nataraj NB., Haga Y., Drago-Garcia D., Marrocco I., Sekar A., Ghosh S., Vaknin I., Lebon S., Kramarski L., Tsutsumi Y., Choi I., Rueda O M., Caldas C., Yarden Y.: TSHZ2 is an EGF-regulated tumor suppressor that binds the cytokinesis regulator PRC1 and inhibits metastasis, Sci Signal., 2021
[PubMed]
Haga Y., Marrocco I., Noronha A., Uribe M L., Nataraj NB., Sekar A., Drago Garcia D., Borgoni S., Lindzen M, Giri S., Wiemann S., Tsutsumi Y., Yarden Y.: Host-dependent Phenotypic Resistance to EGFR Tyrosine Kinase Inhibitors, Cancer Res., 2021.
[PubMed]
Takamura K., Tachibana K., Kihira T., Nakai K., Tsutsumi Y., Kondoh M. : Legislation on the Roles of the Pharmacist and Pharmacy in the Revision of the Pharmaceutical and Medical Device Act and the Pharmacists Act in Japan., Ther. Innov. Regul. Sci., 2021.
[PubMed]
Ogawa T., Okumura R., Nagano K., Minemura T., Izumi M., Motooka D., Nakamura S., Iida T., Maeda Y., Kumanogoh A., Tsutsumi Y., Takeda K. Oral intake of silica nanoparticles exacerbates intestinal inflammation., Biochem. Biophys. Res. Commun., 2021
[PubMed]
2020
Francisco A., Qiao L., Fujii Y., Otomo K., Ishii H., Suzuki T., Tsujino H., Uno T., Tsutsumi Y., Kawashima Y., Takagi T., Murai K., Nemoto T., Arisawa M. : Absorption, Fluorescence, and Two-photon Excitation Ability of 5-Phenylisolidolo[2,1-a]quinolines., ACS Omega, 5(5): 2473-9, 2020. [PubMed]
Lin Y., Higashisaka K., Shintani T., Maki A., Hanamuro S., Haga Y., Maeda S., Tsujino H., Nagano K., Fujio Y., Tsutsumi Y. : Progesterone receptor membrane component 1 leads to erlotinib resistance, initiating crosstalk of Wnt/β-catenin and NF-κB pathways, in lung adenocarcinoma cells., Sci. Rep., 10(1): 4748, 2020. [PubMed]
Inoue M., Tsuji Y., Yoshimine C., Enomoto S., Morita Y., Osaki N., Kunishige M., Miki M., Amano S., Yamashita K., Kamada H., Tsutsumi Y., Tsunoda S. : Structural optimization of a TNFR1-selective antagonistic TNF-α mutant to create new-modality TNF-regulating biologics., J. Biol. Chem., 295(28): 9379-91, 2020. [PubMed]
Takamura K., Tachibana K., Kusakabe T., Nakai K., Tsutsumi Y., Kondoh M. : New Japanese Regulatory Frameworks for Post-marketing Management of Pharmaceutical Products. Pharmaceutical Research, 2020. [PubMed]
Takamura K., Tachibana K., Kihira T., Nakai K., Tsutsumi Y., Kondoh M. : Legislation on the roles of the pharmacist and pharmacy in the revision of the pharmaceutical and medical device and the pharmacist act in Japan. Ther. Innov. Regul. Sci., 2020. [PubMed]
Matsushita S., Tachibana K., Kusakabe T., Hirayama R., Tsutsumi Y., Kondoh M. : The roadmap to approval under Japan's two track regulatory system: comparing six regenerative medical products. Cell Stem Cell, 2020. [PubMed]
Tao H., Nagano K., Tasaki I., Zhang TQ., Ishizaka T., Gao JQ., Harada K., Hirata K., Tsujino H., Higashisaka K., Tsutsumi Y. : Development and evaluation of a system for the semi-quantitative determination of the physical properties of skin after exposure to silver nanoparticles. Nanoscale Res. Lett., 2020. [PubMed]
Maki A., Lin Y., Aoyama M., Sato K., Gao JQ., Tsujino H., Nagano K., Higashisaka K., Tsutsumi Y. : Silver nanoparticles induce DNA hypomethylation through proteasome-mediated degradation of DNA methyltransferase 1. Biol. Pharm. Bull, 2020. [PubMed]
Haga Y., Higashisaka K., Yang L., Sekine N., Lin Y., Tsujino H., Nagano K., Tsutsumi Y. : Inhibition of Akt/mTOR pathway overcomes intrinsic resistance to dasatinib in triple-nagative breast cancer. Biochem. Biophys. Res. Commun., 2020. [PubMed]
2019
Nakashima A., Higashisaka K., Kusabiraki T., Aoki A., Ushijima A., Ono Y., Tsuda S., Shima T., Yoshino O., Nagano K., Yoshioka Y., Tsutsumi Y., Saito S.: Autophagy is a new protective mechanism against the cytotoxicity of platinum nanoparticles in human trophoblasts., Sci. Rep., 2019.
[PubMed]
Srivastava S., Nataraj N.B., Sekar A., Ghosh S., Bornstein C., Drago-Garcia D., Roth L, Romaniello D., Marrocco I., David E., Gilad Y., Lauriola M., Rotkopf R., Kimchi A., Haga Y., Tsutsumi Y., Mirabeau O., Surdez, D., Zinovyev, A., Delattre, O., Kovar, H., Amit, I., Yarden, Y.: ETS Proteins Bind with Glucocorticoid Receptors: Relevance for Treatment of Ewing Sarcoma., Cell Rep., 2019.
[PubMed]
Attia T.Z., Yamashita T., Tsujino H., Derayea S.M., Tsutsumi Y., Uno T.: Effect of drug combination on omeprazole metabolism by cytochrome P450 2C19 in helicobacter pylori eradication therapy., Chem. Pharm. Bull., 2019.
[PubMed]
Yamashita T., Kamada H., Kanasaki S., Nagano K., Inoue M., Higashisaka K., Yoshioka Y., Tsutsumi Y., Tsunoda S.: Ephrin type-A receptor 2 on tumor-derived exosomes enhances angiogenesis through the activation of MAPK signaling., Pharmazie. 2019.
[PubMed]
Yoshioka S., Takehara T., Matsuzaki T., Suzuki T., Tsujino H., Uno T., Tsutsumi Y., Murai K., Fujioka H., Arisawa, M: Direct synthesis of dialkylarylvinylsilane derivatives: Metathesis of dialkylaryl-iso-propenylsilane and its application to tetracyclic silacycle dye synthesis., Chem Commun., 2019.
[PubMed]
Ishizaka T., Nagano K., Tasaki I., Tao H., Gao J.-Q., Harada K., Hirata K., Saito S., Tsujino H., Higashisaka K., Tsutsumi Y.: Optimization and Evaluation of Pretreatment Method for sp-ICP-MS to Reveal the Distribution of Silver Nanoparticles in the Body., Nanoscale Res. Lett., 2019.
[PubMed]
2018
Higashisaka K., Nakashima A., Iwahara Y., Aoki A., Nakayama M., Yanagihara I., Lin Y., Nagano K., Tsunoda S., Saito S., Yoshioka Y., Tsutsumi Y. : Neutrophil depletion exacerbates pregnancy complications, including placental damage, induced by silica nanoparticles in mice., Front. Immunol., 2018.
[PubMed]
Shintani T., Higashisaka K., Maeda M., Hamada M., Tsuji R., Kurihara K., Kashiwagi Y., Sato A., Obana M., Yamamoto A., Kawasaki K., Lin Y., Kijima T., Kinehara Y., Kumagai T., Imamura F., Miwa Y., Maeda S., Morii E., Kumanogoh A., Tsutsumi Y., Nagatomo I., Fujio Y. : Eukaryotic translation initiation factor 3 subunit C is associated with acquired resistance to erlotinib in non-small cell lung cancer., Oncotarget, 2019.
[PubMed]
Nakashima A., Higashisaka K., Kusabiraki T., Aoki A., Ushijima A., Ono Y., Tsuda S., Shima T., Yoshino O., Nagano K., Yoshioka Y., Tsutsumi Y., Saito S. : Autophagy is a new protective mechanism against the cytotoxicity of platinum nanoparticles in human trophoblasts., Scientific Reports., 2019.
[PubMed]
2017
Aoyama M., Yoshioka Y., Arai Y., Hirai H., Ishimoto R., Nagano K., Higashisaka K., Nagai T., Tsutsumi Y. : Intracellular trafficking of particles inside endosomal vesicles is regulated by particle size., J. Controlled Release., 2017.
[PubMed]
Kuwagata M., Kumagai F., Saito Y., Higashisaka K., Yoshioka Y., Tsutsumi Y. : Permeability of skin to silver nanoparticles after epidermal skin barrier disruption in rats., Fund. Toxicol. Sci., 2017.
2016
Arai M., Kawachi T., Kotoku N., Nakata C., Kamada H., Tsunoda S., Tsutsumi Y., Endo H., Inoue M., Sato H., Kobayashi M. : Furospinosulin-1, marine spongean furanosesterterpene, suppresses the growth of hypoxia-adapted cancer cells by binding to transcriptional regulators p54nrb and LEDGF/p75., Chembiochem., 2016.
[PubMed]
Ando D., Kamada H., Inoue M., Taki S., Furuya T., Abe Y., Nagano K., Tsutstumi Y., Tsunoda S. : Generation of a selective TNFR2-specific murine assays system., Pharmazie., 2016.
[PubMed]
Hirai T., Yoshioka Y., Takahashi H., Handa T., Izumi N., Mori T., Uemura E., Nishijima N., Sagami K., Yamaguchi M., Eto S., Nagano K., Kamada H., Tsunoda S., Ishii K., Higashisaka K., Tsutsumi Y. : High-dose cutaneous exposure to mite allergen induces IgG-mediated protection against anaphylaxis., Clin. Exp. Allergy., 2016.
[PubMed]
Hirai T., Yoshioka Y., Izumi N., Ichihashi K., Handa T., Nishijima N., Uemura E., Sagami K., Takahashi H., Yamaguchi M., Nagano K., Mukai Y., Kamada H., Tsunoda S., Ishii K., Higashisaka K., Tsutsumi Y. : Metal nanoparticles in the presence of lipopolysaccharides trigger the onset of metal allergy in mice., Nature Nanotechnology (Nat. Nanotechnol.), 2016.
[PubMed]
Uemura E., Yoshioka Y., Hirai T., Handa T., Nagano K., Higashisaka K., Tsutsumi Y. : Relationship between size and surface modification of silica particles and enhancement and suppression of inflammatory cytokine production by lipopolysaccharide or peptidoglycan stimulated RAW264.7 macrophages., J. Nanopart. Res., 2016.
Ando D., Inoue M., Kamada H., Taki S., Furuya T., Abe Y., Nagano K., Tsutsumi Y., Tsunoda S. : Creation of mouse TNFR2-selective agonistic TNF mutants using a phage display technique., Biochem. Biophs. Rep., 2016.
Morishita Y., Yoshioka Y., Takimura Y., Shimizu Y., Namba Y., Nojiri N., Ishizaka T., Takao K., Yamashita F., Takuma K., Ago Y., Nagano K., Mukai Y., Kamada H., Tsunoda S., Saito S., Matsuda T., Hashida M., Miyakawa T., Higashisaka K., Tsutsumi Y. : Distribution of silver nanoparticles to breast milk and their biological effects on breast-fed offspring mice., ACS NANO., 2016.
[PubMed]
Nagano K., Tsutsumi Y. : Development of novel drug delivery systems using phage display technology for clinical application of protein drugs., Proceedings of the Japan Academy, Ser. B. (Proc Jpn Acad Ser B), 2016.
Miyawaki A., Mitsuhara Y., Orimoto A., Nakayasu Y., Tsunoda S., Obana M., Maeda M., Nakayama H., Yoshioka Y., Tsutsumi Y., Fujio Y. : Moesin is activated in cardiomyocytes in experimental autoimmune myocarditis and mediates cytoskeletal reorganization with protrusion formation., Am J Physiol Heart Circ Physiol., 2016.
[PubMed]
Isoda K., Daibo T., Yushina K., Yoshioka Y., Tsutsumi Y., Akimoto Y., Kawakami H., Taira Y., Taira I., Yanoshita R., Nishimura T., Ishida I. : Hepatotoxicity, nephrotoxicity, and drug/chemical interaction toxicity of platinum nanoparticles in mice., Pharmazie., 2016.
Hirai T., Yoshioka Y., Udaka A., Uemura E., Ohe T., Aoshima H., Gao J., Kokubo K., Oshima T., Nagano K., Higashisaka K., Mashino T., Tsutsumi Y. : Potential suppressive effects of two C60-fullerene derivatives on acquired immunity., Nanoscale Res Lett., 2016.
[PubMed]
Aoyama M., Hata K., Higashisaka K., Nagano K., Yoshioka Y., Tsutsumi Y. : Clusterin in the protein corona plays a key role in the stealth effect of nanoparticles against phagocytes., Biochem. Biophys. Res. Commun., 2016.
[PubMed]
Yuan Z., Li Y., Hu Y., Higashisaka K., Nagano K., Tsutsumi Y., Gao JQ. : Chitosan nanoparticles and their Tween 80 modified counterparts disrupt the developmental profile of zebrafish embryos., Int. J. Pharm., 2016
[PubMed]
Imai S., Morishita Y., Hata T., Kondoh M., Yagi K., Gao JQ., Nagano K., Higashisaka K., Yoshioka Y., Tsutsumi Y.: Cellular internalization, transcellular transport, and cellular effects of silver nanoparticles in polarized Caco-2 cells following apical or basolateral exposure., Biochem. Biophys. Res. Commun., 2017.
[PubMed]
Handa T., Hirai T., Izumi N., Eto S., Tsunoda S., Nagano K., Higashisaka K., Yoshioka Y., Tsutsumi Y. : Identifying a size specific hazard of silica nanoparticles after intravenous administration and its relationship to the other hazards that have negative correlations with the particle size in mice., Nanotechnology., 2017.
[PubMed]
Nagano T., Nagano K., Nabeshi H., Yoshioka Y., Kamada H., Tsunoda S., Gao JQ., Higashisaka K., Yoshioka Y., Tsutsumi Y. : Modifying the surface of silica nanoparticles with amino or carboxyl groups decrease their cytotoxicity to parenchymal hepatocytes., Biol. Pharm. Bull., 2017.
[PubMed]
Inoue M., Ando D., Kamada H., Taki S., Niiyama M., Mukai Y., Tadokoro T., Maenaka K., Nakayama T., Kado Y., Inoue T., Tsutsumi Y., Tsunoda S. : A trimeric structural fusion of an antagonistic tumor necrosis factor-alpha mutant enhances molecular stability and enables facile modification., J. Biol. Chem., 2017.
[PubMed]
Nishijima N., Hirai T., Misato K., Aoyama M., Kuroda E., Ishii K., Higashisaka K., Yoshioka Y., Tsutsumi Y. : Human scavenger receptor A1-mediated inflammatory response to silica particle exposure is size-spesific., Front. Immunol., 2017.
[PubMed]
Higashisaka K., Nagano K., Yoshioka Y., Tsutsumi Y. : Nano-safety research: Examining the Associations among the biological effects of nanoparticles and their physicochemical properties and kinetics., Biol. Pharm. Bull., 2017.
[PubMed]
2015
Yoshida T., Yoshioka Y., Morishita Y., Aoyama M., Tochigi S., Hirai T., Tanaka K., Nagano K., Kamada H., Tsunoda S., Nabeshi H., Yoshikawa T., Higashisaka K., Tsutsumi Y. : Protein corona changes mediated by surface modification of amorphous silica nanoparticles suppress acute toxicity and activation of intrinsic coagulation cascade in mice., Nanotechnology., 26(24):245101, 2015.[PubMed]
Hirai T., Yoshioka Y., Takahashi H., Ichihashi K., Udaka A., Mori T., Nishijima N., Yoshida T., Nagano K., Kamada H., Tsunoda S., Takagi T., Ishii K., Nabeshi H., Yoshikawa T., Higashisaka K., Tsutsumi Y. : Cutaneous exposure to agglomerates of silica nanoparticles and allergen results in IgE-biased immune response and increased sensitivity to anaphylaxis in mice., Part. Fibre. Toxicol[PubMed]
Wakimoto T., Uchida K., Mimura K., Kanagawa T., Mehandjiev TR., Aoshima H., Kokubo K., Mitsuda N., Yoshioka Y., Tsutsumi Y., Kimura T., Yanagihara I. : Hydroxylated Fullerene: a potential anti-inflammatory and anti-oxidant agent for preventing mouse preterm birth., Am. J. Obstet. Gynecol., 213(5):708, 2015.[PubMed]
Arai M., Kawachi T., Kotoku N., Nakata C., Kamada H., Tsunoda S., Tsutsumi Y., Endo H., Inoue M., Sato H., Kobayashi M. : Furospinosulin-1, marine spongean furanosesterterpene, suppresses the growth of hypoxia-adapted cancer cells by binding to transcriptional regulators p54nrb and LEDGF/p75., Chembiochem., 17(2):181-9, 2016[PubMed]
Taki S., Kamada H., Inoue M., Nagano K., Mukai Y., Higashisaka K., Yoshioka Y., Tsutsumi Y., Tsunoda S. A novel bispecific antibody against human CD3 and Ephrin receptor A10 for breast cancer therapy., PLOS ONE, 10(12):e0144712, 2015.[PubMed]
Ando D., Kamada H., Inoue M., Taki S., Furuya T., Abe Y., Nagano K., Tsutstumi Y., Tsunoda S. : Generation of a selective TNFR2-specific murine assays system., Pharmazie., in press.
Hirai T., Yoshioka Y., Takahashi H., Handa T., Izumi N., Mori T., Uemura E., Nishijima N., Sagami K., Yamaguchi M., Eto S., Nagano K., Kamada H., Tsunoda S., Ishii K., Higashisaka K., Tsutsumi Y.: High-dose cutaneous exposure to mite allergen induces IgG-mediated protection against anaphylaxis., Clin. Exp. Allergy, in press.[PubMed]
Higashisaka K., Yoshioka Y., Tsutsumi Y. : Applications and safety of nanomaterials used in the food industry., Food Safety., 3(2), 39-47, 2015
Hirai T., Yoshioka Y., Higashisaka K., Tsutsumi Y. : Potential hazards of skin exposure to nanoparticles., Biological Effects of Fibrous and Particulate Substances., Springer., 123-35, 2015.
Morishita Y., Yoshioka Y., Higashisaka K., Tsutsumi Y. : Reproductive and developmental effects of nanomaterials., Biological Effects of Fibrous and Particulate Substances., Springer., 77-101, 2015.
Nakamura T., Mukai Y., Tsutsumi Y., Yamagata Y. : Structural basis for signal initiation by TNF and TNFR., Protein modifications in pathogenic dysregulation of signaling., Springer., 126-41, 2015.
Yoshioka Y., Higashisaka K., Tsutsumi Y. : Biocompatibility of nanomaterials., Nanomaterials in Pharmacology., Springer., 185-99, 2015.
Nagano K., Tsutsumi Y. : Development of novel drug delivery systems using phage display technology for clinical application of protein drugs., Proceedings of the Japan Academy, Ser. B., in press.
2014
Higashisaka K., Fujimura M., Taira M., Yoshida T., Tsunoda S., Baba T., Yamaguchi N., Nabeshi N., Yoshikawa T., Nasu M., Yoshioka Y., Tsutsumi Y.：Asian dust particles induce macrophage inflammatory responses via mitogen-activated protein kinase activation and reactive oxygen species production., J Immunol Res., 2014:856154, 2014.[PubMed]
Nagano K., Yamashita T., Inoue M., Higashisaka K., Yoshioka Y., Abe Y., Mukai Y., Kamada H., Tsutsumi Y., Tsunoda S. : Eph receptor A10 has a potential as a target for a prostate cancer therapy., Biochem. Biophys. Res. Commun., 450(1):545-9, 2014.[PubMed]
Nagano K., Maeda Y., Kanasaki S., Watanabe T., Yamashita T., Inoue M., Higashisaka K., Yoshioka Y., Abe Y., Mukai Y., Kamada H., Tsutsumi Y., Tsunoda S. : Ephrin receptor A10 is a promising drug target potentially useful for breast cancers including triple negative breast cancers., J. Controlled Release., 189:72-9, 2014.[PubMed]
Yoshida T., Yoshioka Y., Takahashi H., Misato K., Mori T., Hirai T., Nagano K., Abe Y., Mukai Y., Kamada H., Tsunoda S., Nabeshi H., Yoshikawa T., Higashisaka K., Tsutsumi Y. : Intestinal absorption and biological effects of orally administered amorphous silica particles., Nanoscale Res Lett., 9:532, 2014.[PubMed]
Higashisaka K., Kunieda A., Iwahara Y., Tanaka K., Nagano K., Mukai Y., Kamada H., Tsunoda S., Yoshioka Y., Tsutsumi Y. : Neutrophilia due to silica nanoparticles induces release of double-stranded DNA., Journal of Nanomedicine & Nanotechnology., 5(5):1000236, 2014.
Imai S., Yoshioka Y., Morishita Y., Yoshida T., Uji M., Nagano K., Mukai Y., Kamada H., Tsunoda S., Higashisaka K., Tsutsumi Y. : Size and surface modification of amorphous silica particles determine their effects on the activity of human CYP3A4 in vitro., Nanoscale Res Lett., 9(1):651, 2014.[PubMed]
Hata K., Higashisaka K., Nagano K., Mukai Y., Kamada H., Tsunoda S., Yoshioka Y., Tsutsumi Y. : Evaluation of silica nanoparticle binding to major human blood proteins., Nanoscale Res Lett., 9:668,2014
Kamada H., Taki S., Nagano K., Inoue M., Ando D., Mukai Y., Higashisaka K., Yoshioka Y., Tsutsumi Y., Tsunoda S. : Generation and characterization of a bispecific Diabody targeting EPH receptor A10 and CD3., Biochem. Biophys. Res. Commun., 456(4):908-12, 2015.[PubMed]
Inoue M., Kamada H., Abe Y., Higashisaka K., Nagano K., Mukai Y., Yoshioka Y., Tsutsumi Y., Tsunoda S. : Aminopeptidase P3 (APP3), a novel member of the TNF/TNFR2 signaling complex induces phosphorylation of JNK., J. Cell Science, 128(4):656-69,2015[PubMed]
Isoda K., Kondoh M., Yoshioka Y., Tsutsumi Y., Imazawa T., Nishimura T., Ishida I., Yagi K. : Silica nanoparticle-induced toxicity in mouse lung and liver imaged by electron microscopy., Fund. Toxicol. Sci., 2(1):19-23, 2015.
Yoshioka Y., Tsutsumi Y. : Recent topics on development of nanomaterials and nano-safety science., Yakugaku Zasshi., 134(6), 721-2, 2014.[PubMed]
Yoshioka Y., Tsutsumi Y. : Nano-safety Science for Sustainable Nanotechnology., Yakugaku Zasshi., 134(6), 737-42, 2014.[PubMed]
東阪和馬：薬学新素材としてのナノマテリアルの生体防御機構に及ぼす影響解析., Yakugaku Zasshi., 134(10), 1043-8, 2014.[PubMed]
Yoshioka Y., Higashisaka K., Tsutsumi Y. : Biocompatibility of nanomaterials., Nanomaterials in Pharmacology., in press.
Yoshioka Y., Higashisaka K., Tsunoda S., Tsutsumi Y. : The absorption, distribution, metabolism, and excretion profile of nanoparticles., Engineered Cell Manipulation for Biomedical Application., pp. 259-71, 2014.
2013
Yamashita K., Yoshioka Y., Pan H., Taira M., Ogura T., Nagano T., Aoyama M., Nagano K., Abe Y., Kamada H., Tsunoda SI., Aoshima H., Nabeshi H., Yoshikawa T., Tsutsumi Y.
Biochemical and hematologic effects of polyvinylpyrrolidone-wrapped fullerene C60 after oral administration.
Pharmazie., 68(1):54-7, 2013.[PubMed]
Morishige T., Yoshioka Y., Narimatsu S., Ikemizu S., Tsunoda S., Tsutsumi Y., Mukai Y., Okada N., Nakagawa S.
Mutants of lymphotoxin-α with augmented cytotoxic activity via TNFR1 for use in cancer therapy.
Cytokine., 61(2):578-84, 2013.[PubMed]
Takano M., Yamashita T., Nagano K., Otani M., Maekura K., Kamada H., Tsunoda S., Tsutsumi Y., Tomiyama T., Mori H., Matsuura K., Matsuyama S.
Proteomic analysis of the hippocampus in Alzheimer's disease model mice by using two-dimensional fluorescence difference in gel electrophoresis.
Neuroscience Letters., 534:85-9, 2013.[PubMed]
Yoshikawa M., Mukai Y., Okada Y., Tsumori Y., Tsunoda S., Tsutsumi Y., Aird WC., Yoshioka Y., Okada N., Doi T., Nakagawa S.
Robo4 is an effective tumor endothelial marker for antibody-drug conjugates based on the rapid isolation of the anti-Robo4 cell-internalizing antibody.
Blood., 121(14):2804-13, 2013.[PubMed]
Yamagishi Y., Watari A., Hayata Y., Li X., Kondoh M., Tsutsumi Y., Yagi K.
Hepatotoxicity of sub-nanosized platinum particles in mice.
Pharmazie., 68(3):178-82, 2013.[PubMed]
Yoshioka Y., Tsutsumi Y.
Resent topics on development of nanomaterials and nano-safety science. Yakugaku Zasshi., 133(2):149-50, 2013.[PubMed]
Yoshioka Y., Yoshikawa T., Nabeshi H., Tsutsumi Y.
Recent topics about nano-safety science and its future.
Yakugaku Zasshi., 133(2):169-74, 2013.[PubMed]
Yamashita T., Kamada H., Kanasaki S., Maeda Y., Nagano K., Abe Y., Inoue M., Yoshioka Y., Tsutsumi Y., Katayama S., Inoue M., Tsunoda S.
Epidermal growth factor receptor localized to exosome membranes as a possible biomarker for lung cancer diagnosis.
Pharmazie., in press.
Yoshida T., Yoshioka Y., Tochigi S., Hirai T., Uji M., Ichihashi K., Nagano K., Abe Y., Kamada H., Tsunoda S., Nabeshi H., Higashisaka K., Yoshikawa T., Tsutsumi Y.
Intranasal exposure to amorphous nanosilica particles could activate intrinsic coagulation cascade and platelets in mice.
Part. Fibre. Toxicol., in press.
Nagano T., Higashisaka K., Kunieda A., Iwahara Y., Tanaka K., Nagano K., Abe Y., Kamada H., Tsunoda S., Nabeshi H., Yoshikawa T., Yoshioka Y., Tsutsumi Y.
Liver-specific microRNAs as biomarkers of nanomaterial-induced liver damage.
Nanotechnology., in press.
Yamagishi Y., Watari A., Hayata Y., Li X., Kondoh M., Yoshioka Y., Tsutsumi Y., Yagi K.
Acute and chronic nephrotoxicity of platinum nanoparticles in mice.
Nanoscale Res. Lett., in press.
2012
Kitagaki M., Isoda K., Kamada H., Kobayashi T., Tsunoda S., Tsutsumi Y., Niida T., Kujiraoka T., Ishigami N., Ishihara M., Matsubara O., Ohsuzu F., Kikuchi M. : Novel TNF-alpha receptor-1 antagonist treatment attenuates arterial inflammation and intimal hyperplasia in mice., J. Atheroscler. Thromb., 2012.
[PubMed]
Nabeshi H., Yoshikawa T., Matsuyama K., Nakazato Y., Arimori A., Isobe M., Tochigi S., Kondoh S., Hirai T., Akase T., Yamashita T., Yamashita K., Yoshida T., Nagano K., Abe Y., Yoshioka Y., Kamada H., Imazawa T., Kondoh M., Yagi K., Mayumi T., Itoh N., Tsunoda S., Tsutsumi Y. : Amorphous nanosilicas induce consumptive coagulopathy after systemic exposure., Nanotechnol., 2012.
[PubMed]
Hirai T., Yoshikawa T., Nabeshi H., Yoshida T., Tochigi S., Ichihashi K., Uji M., Akase T., Nagano K., Abe Y., Kamada H., Itoh N., Tsunoda S., Yoshioka Y., Tsutsumi Y. : Amorphous silica nanoparticles size-dependently aggravate atopic dermatitis-like skin lesions following an intradermal injection., Part. Fibre. Toxicol., 2012.
[PubMed]
Yamashita T., Okamura T., Nagano K., Imai S., Abe Y., Nabeshi H., Yoshikawa T., Yoshioka Y., Kamada H., Tsutsumi Y., Tsunoda S. : Rho GDP-dissociation inhibitor alpha is associated with cancer metastasis in colon and prostate cancer., Pharmazie, 2012.
[PubMed]
Yamashita T., Nagano K., Kanasaki S., Maeda Y., Furuya T., Inoue M., Nabeshi H., Yoshikawa T., Yoshioka Y., Itoh N., Abe Y., Kamada H., Tsutsumi Y., Tsunoda S. : Annexin A4 is a possible biomarker for cisplatin susceptibility of malignant mesothelioma cells., Biochem. Biophys. Res. Commun., , 2012.
[PubMed]
Morishita Y., Yoshioka Y., Satoh H., Nojiri N., Nagano K., Abe Y., Kamada H., Tsunoda S., Nabeshi H., Yoshikawa T., Tsutsumi Y. : Distribution and histological effects of intravenously administered amorphous nanosilica particles in the testes of mice., Biochem. Biophys. Res. Commun., 2012.
[PubMed]
Morishige T., Yoshioka Y., Inakura H., Tanabe A., Narimatsu S., Yao X., Monobe Y., Imazawa T., Tsunoda S., Tsutsumi Y., Mukai Y., Okada N., Nakagawa S. : Suppression of nanosilica particle–induced inflammation by surface modification of the particles., Arch. Toxicol., 2012.
[PubMed]
Hirai T., Yoshikawa T., Nabeshi H., Yoshida T., Tochigi S., Uji M., Ichihashi K., Akase T., Nagano K., Abe Y., Kamada H., Tsunoda S., Yoshioka Y., Itoh N., Tsutsumi Y. : Dermal absorption of amorphous nanosilica particles after topical exposure for three days., Pharmazie., 2012.
[PubMed]
Yoshida T., Matsuyama K., Yoshikawa T., Nabeshi H., Nakazato Y., Tochigi S., Hirai T., Uji M., Ichihashi K., Akase T., Nagano K., Abe Y., Kamada H., Tsunoda S., Yoshioka Y., Itoh N., Tsutsumi Y. : Amorphous nanosilica particles induce ROS generation in Langerhans cells., Pharmazie., 2012.
[PubMed]
Nagano T., Yoshioka Y., Higashisaka K., Kunieda A., Hata K., Nagano K., Abe Y., Kamada H., Tsunoda S., Nabeshi H., Yoshikawa T., Tsutsumi Y. : Potential of acute-phase proteins as biomarkers for sub-nano platinum exposure., Pharmazie., 2012.
[PubMed]
Hirai T., Yoshioka Y., Takahashi H., Ichihashi K., Yoshida T., Tochigi S., Nagano K., Abe Y., Kamada H., Tsunoda S., Nabeshi H., Yoshikawa T., Tsutsumi Y. : Amorphous silica nanoparticles enhance cross-presentation in murine dendritic cells., Biochem. Biophys. Res. Commun., 2012.
[PubMed]
Higashisaka K., Yoshioka Y., Yamashita K., Morishita Y., Pan H., Ogura T., Nagano T., Kunieda A., Nagano K., Abe Y., Kamada H., Tsunoda S., Nabeshi H., Yoshikawa T., Tsutsumi Y. : Hemopexin as biomarkers for analyzing the biological responses associated with exposure to silica nanoparticles., Nanoscale Res. Lett., 2012.
[PubMed]
Yoshida T., Yoshioka Y., Matsuyama K., Nakazato Y., Tochigi S., Hirai T., Kondoh S., Nagano K., Abe Y., Kamada H., Tsunoda S., Nabeshi H., Yoshikawa T., Tsutsumi Y. : Surface modification of amorphous nanosilica particles suppresses nanosilica-induced cytotoxicity, ROS generation, and DNA damage in various mammalian cells., Biochem. Biophys. Res. Commun., 2012.
[PubMed]
2011
Higashisaka K., Yoshioka Y., Yamashita K., Morishita Y., Fujimura M., Nabeshi H., Nagano K., Abe Y., Kamada H., Tsunoda S., Yoshikawa T., Itoh N., Tsutsumi Y. : Acute phase proteins as biomarkers for predicting the exposure and toxicity of nanomaterials., Biomaterials., 2011.
[PubMed]
Imai S., Nagano K., Yoshida Y., Okamura T., Yamashita T., Abe Y., Yoshikawa T., Yoshioka Y., Kamada H., Mukai Y., Nakagawa S., Tsutsumi Y., Tsunoda S. : Development of an antibody proteomics system using a phage antibody library for efficient screening of tumor-related biomarker proteins., Biomaterials., 2011.
[PubMed]
Nomura T., Abe Y., Kamada H., Shibata H., Kayamuro H., Inoue M., Kawara T., Arita S., Furuya T., Yamashita T., Nagano K., Yoshikawa T., Yoshioka Y., Mukai Y., Nakagawa S., Taniai M., Ohta T., Serada S., Naka T., Tsunoda S., Tsutsumi Y. : Therapeutic effect of PEGylated TNFR1-selective antagonistic mutant TNF in experimental autoimmune encephalomyelitis mice., J. Control. Release., 2011.
[PubMed]
Nabeshi H., Yoshikawa T., Matsuyama K., Nakazato Y., Matsuo K., Arimori A., Isobe M., Tochigi S., Kondoh S., Hirai T., Akase T., Yamashita T., Yamashita K., Yoshida T., Nagano K., Abe Y., Yoshioka Y., Kamada H., Imazawa T., Nakagawa S., Mayumi T., Itoh N., Tsunoda S., Tsutsumi Y. : Systemic distribution, nuclear entry and cytotoxicity of amorphous nanosilica following topical application., Biomaterials., 2011.
[PubMed]
Yoshida Y., Yamashita T., Nagano K., Imai S., Nabeshi H., Yoshikawa T., Yoshioka Y., Abe Y., Kamada H., Tsutsumi Y., Tsunoda S. : Limited expression of reticulocalbin-1 in lymphatic endothelial cells in lung tumor but not in normal lung., Biochem. Biophys. Res. Commun., 2011.
[PubMed]
Yamashita K., Yoshioka Y., Higashisaka K., Mimura K., Morishita Y., Nozaki M., Yoshida T., Ogura T., Nabeshi H., Nagano K., Abe Y., Kamada H., Monobe Y., Imazawa T., Aoshima H., Shishido K., Kawai Y., Mayumi T., Tsunoda S., Itoh N., Yoshikawa T., Yanagihara I., Saito S., Tsutsumi Y. : Silica and titanium dioxide nanoparticles cause pregnancy complications in mice., Nature Nanotechnology (Nat. Nanotechnol.), 2011.
[PubMed]
Yoshikawa M., Mukai Y., Tsunoda S., Tsutsumi Y., Yoshioka Y., Okada N., Nakagawa S. : Modifying the antigen-immunization schedule improves the variety of monoclonal antibodies obtained from immune-phage antibody libraries against HIV-1 Nef and Vif., J. Biosci. Bioeng., 2011.
[PubMed]
Nabeshi H., Yoshikawa T., Arimori A., Yoshida T., Tochigi S., Kondoh S., Hirai T., Akase T., Nagano K., Abe Y., Kamada H., Tsunoda S., Itoh N., Yoshioka Y., Tsutsumi Y. : Effect of surface properties of silica nanoparticles on their cytotoxicity and cellular distribution in murine macrophages., Nanoscale Res. Lett., 2011.
[PubMed]
Nabeshi H., Yoshikawa T., Matsuyama K., Nakazato Y., Tochigi S., Kondoh S., Hirai T., Akase T., Yamashita T., Yamashita K., Yoshida T., Nagano K., Abe Y., Yoshioka Y., Kamada H., Imazawa T., Itoh N., Tsunoda S., Tsutsumi Y. : Amorphous nanosilica induce endocytosis-dependent ROS generation and DNA damage in human keratinocytes., Part. Fibre. Toxicol., 2011.
[PubMed]
Li X., Kondoh M., Watari A., Hasezaki T., Isoda K., Tsutsumi Y., Yagi K. : Effect of 70-nm silica particles on the toxicity of acetaminophen, tetracycline, trazodone, and 5-aminosalicylic acid in mice., Pharmazie., 2011.
[PubMed]
Isoda K., Hasezaki T., Kondoh M., Tsutsumi Y., Yagi K. : Effect of surface charge on nano-sized silica particles-induced liver injury., Pharmazie., 2011.
[PubMed]
Yoshida T., Yoshioka Y., Fujimura M., Yamashita K., Higashisaka K., Morishita Y., Kayamuro H., Nabeshi H., Nagano K., Abe Y., Kamada H., Tsunoda S., Itoh N., Yoshikawa T., Tsutsumi Y. : Promotion of allergic immune responses by intranasally-administrated nanosilica particles in mice., Nanoscale Res. Lett., 2011.
[PubMed]
Abe Y., Yoshikawa T., Inoue M., Nomura T., Furuya T., Yamashita T., Nagano K., Nabeshi H., Yoshioka Y., Mukai Y., Nakagawa S., Kamada H., Tsutsumi Y., Tsunoda S. : Fine tuning of receptor-selectivity for tumor necrosis factor-α using a phage display system with one-step competitive panning., Biomaterials., 2011.
[PubMed]
Diao Y.Y., Li H.Y., Fu Y.H., Jiang H.L., Tsutsumi Y., Wei Q.C., Gao J.Q. : Doxorubicin-loaded PEG-PCL copolymer micelles enhance cytotoxicity and intracellular accumulation of doxorubicin in adriamycin-resistant tumor cells., Int. J. Nanomedicine., 2011.
[PubMed]
Hirai T., Yoshikawa T., Nabeshi H., Yoshida T., Tochigi S., Uji M., Ichihashi K., Akase T., Yamashita T., Yamashita K., Nagano K., Abe Y., Kamada H., Tsunoda S., Yoshioka Y., Itoh N., Tsutsumi Y. : Size-dependent immune-modulating effect of amorphous nanosilica particles., Pharmazie., 2011.
[PubMed]
Nabeshi H., Yoshikawa T., Akase T., Yoshida T., Tochigi S., Hirai T., Uji M., Ichihashi K., Yamashita T., Higashisaka K., Morishita Y., Nagano K., Abe Y., Kamada H., Tsunoda S., Itoh N., Yoshioka Y., Tsutsumi Y. : Effect of amorphous silica nanoparticles on in vitro RANKL-induced osteoclast differentiation in murine macrophages., Nanoscale Res. Lett., 2011.
[PubMed]
Morishita Y., Yamashita K., Yoshikawa T., Terada Y., Nabeshi H., Yoshioka Y., Itoh N., Tsutsumi Y.：Detection of titanium dioxide particles on frozen tissue sections using synchrotron radiation X-ray fluorescence analysis., Pharmazie., 2011.
[PubMed]
Hasezaki T., Isoda K., Kondoh M., Tsutsumi Y., Yagi K. : Hepatotoxicity of silica nanoparticles with a diameter of 100 nm., Pharmazie., 2011.
[PubMed]
Narimatsu S., Yoshioka Y., Watanabe H., Masano T., Morishige T., Yao X., Tanabe A., Tsunoda S., Tsutsumi Y., Mukai Y., Okada N., Nakagawa S. : Lysine-deficient lymphotoxin-α mutant for site-specific PEGylation., Cytokine., 2011.
[PubMed]
Narimatsu S., Yoshioka Y., Morishige T., Yao X., Tsunoda S., Tsutsumi Y., Nishimura MI., Mukai Y., Okada N., Nakagawa S. : Structure–activity relationship of T-cell receptors based on alanine scanning., Biochem. Biophys. Res. Commun., 2011.
[PubMed]
2010
Nomura T., Abe Y., Kamada H., Inoue M., Kawara T., Arita S., Furuya T., Minowa K., Yoshioka Y., Shibata H., Kayamuro H., Yamashita T., Nagano K., Yoshikawa T., Mukai Y., Nakagawa S., Tsunoda S., Tsutsumi Y.
Creation of an improved mutant TNF with TNFR1-selectivity and antagonistic activity by phage display technology.
Pharmazie., 65(2):93-96, 2010. [PubMed]
Morishige T., Yoshioka Y., Tanabe A., Yao X., Mizuguchi, H., Tsunoda S., Tsutsumi Y., Mukai Y., Okada N., Nakagawa S.
Comparison of the anti-tumor activity of native, secreted, and membrane-bound LIGHT in mouse tumor models.
Int. Immunopharmacol., 10(1):26-33, 2010. [PubMed]
Yoshioka Y., Watanabe H., Morishige T., Yao X., Ikemizu S., Nagao C., Ahmad S., Mizuguchi K., Tsunoda S., Tsutsumi Y., Mukai Y., Okada N., Nakagawa S.
Creation of lysine-deficient mutant lymphotoxin-alpha with receptor selectivity by using a phage display system.
Biomaterials., 31(7):1935-1943, 2010. [PubMed]
Shibata H., Abe Y., Yoshioka Y., Nomura T., Sato M., Kayamuro H., Kawara T., Arita S., Furuya T., Nagano K., Yoshikawa T., Kamada H., Tsunoda S., Tsutsumi Y.
Generation of mouse macrophages expressing membrane-bound TNF variants with selectivity for TNFR1- or TNFR2
Cytokine., 50(1):75-83, 2010. [PubMed]
Morishige T., Yoshioka Y., Tanabe A., Yao X., Tsunoda S., Tsutsumi Y., Mukai Y., Okada N., Nakagawa S.
Titanium dioxide induces different levels of IL-1beta production dependent on its particle characteristics through caspase-1 activation mediated by reactive oxygen species and cathepsin B.
Biochem. Biophys. Res. Commun., 392(2):160-165, 2010. [PubMed]
Morishige T., Yoshioka Y., Inakura H., Tanabe A., Yao X., Tsunoda S., Tsutsumi Y., Mukai Y., Okada N., Nakagawa S.
Creation of a LIGHT mutant with the capacity to evade the decoy receptor for cancer therapy.
Biomaterials., 31(12):3357-3363, 2010. [PubMed]
Morishige T., Yoshioka Y., Inakura H., Tanabe A., Yao X., Tsunoda S., Tsutsumi Y., Mukai Y., Okada N., Nakagawa S.
Creation of a lysine-deficient LIGHT mutant with the capacity for site-specific PEGylation and low affinity for a decoy receptor.
Biochem. Biophys. Res. Commun., 393(4):888-893, 2010. [PubMed]
Nabeshi H., Yoshikawa T., Matsuyama K., Nakazato Y., Arimori A., Isobe M., Tochigi S., Kondoh S., Hirai T., Akase T., Yamashita T., Yamashita K., Yoshida T., Nagano K., Abe Y., Yoshioka Y., Kamada H., Imazawa T., Itoh N., Tsunoda S., Tsutsumi Y.
Size-dependent cytotoxic effects of amorphous silica nanoparticles on Langerhans cells.
Pharmazie., 65(3):199-201, 2010. [PubMed]
Kayamuro H., Abe Y., Yoshioka Y., Katayama K., Yoshida T., Yamashita K., Yoshikawa T., Kawai Y., Mayumi T., Hiroi T., Itoh N., Nagano K., Kamada H., Tsunoda Ｓ., Tsutsumi Y.
Mutant TNF-alpha, mTNF-K90R, is a novel mucosal vaccine adjuvant candidate against HIV.
Pharmazie., 65(4):254-6, 2010. [PubMed]
Yamashita K., Yoshioka Y., Higashisaka K., Morishita Y., Yoshida T., Fujimura M., Kayamuro H., Nabeshi H., Yamashita T., Nagano K., Abe Y., Kamada H., Kawai Y., Mayumi T., Yoshikawa T., Itoh N., Tsunoda S., Tsutsumi Y.
Carbon nanotubes elicit DNA damage and inflammatory response relative to their size and shape.
Inflammation., 33(4):276-80, 2010. [PubMed]
Yoshida T., Yoshioka Y., Fujimura M., Kayamuro H., Yamashita K., Higashisaka K., Nakanishi R., Morishita Y., Nabeshi H., Yamashita T., Muroi M., Tanamoto K., Nagano K., Abe Y., Kamada H., Kawai Y., Mayumi T., Itoh N., Yoshikawa T., Tsunoda S., Tsutsumi Y.
Urban aerosol induce pro-inflammatory cytokine production in macrophages and cause airway inflammation in vivo.
Biol. Pharm. Bull., 33(5):780-3, 2010. [PubMed]
Morishige T., Yoshioka Y., Inakura H., Tanabe A., Yao X., Narimatsu S., Monobe Y., Imazawa T., Tsunoda S., Tsutsumi Y., Mukai Y., Okada N., Nakagawa S.
The effect of surface modification of amorphous silica particles on NLRP3 inflammasome mediated IL-1β production, ROS production and endosomal rupture.
Biomaterials., 31(26):6833-6842, 2010. [PubMed]
Nabeshi H., Yoshikawa T., Kamada H., Shibata H., Sugita T., Abe Y., Nagano K., Nomura T., Minowa K., Tsunoda S., Tsutsumi Y.
Arsenic trioxide alters expression and oxidative modification of the proteome in leukemic cells.
Pharmazie., 65:702-707, 2010. [PubMed]
Mukai Y., Nakamura T., Yoshikawa M., Yoshioka Y., Tsunoda S., Nakagawa S., Yamagata Y., Tsutsumi Y.
Solution of the structure of the TNF-TNFR2 complex.
Science Signaling., 3(148), ra83:1-10, 2010. [PubMed]
Morishige T., Yoshioka Y., Inakura H., Tanabe A., Yao X., Tsunoda S., Tsutsumi Y., Mukai Y., Okada N., Nakagawa S.
Cytotoxicity of amorphous silica particles against macrophage-like THP-1 cells depends on particle-size and surface properties.
Pharmazie., 65(8):596-599, 2010. [PubMed]
Kayamuro H., Yoshioka Y., Abe Y., Arita S., Katayama K., , Nomura T., Yoshikawa T., Kubota-Koketsu R., Ikuta K., Okamoto S., Mori Y., Kunisawa J., Kiyono H., Itoh N., Nagano K., Kamada H., Tsutsumi Y., Tsunoda S.
The IL-1 family cytokines as mucosal vaccine adjuvant for the induction of protective immunity against influenza virus.
J. Virol., 84(24):12703-12712, 2010. [PubMed]
Yoshida T., Yoshioka Y., Fujimura M., Yamashita K., Higashisaka K., Nakanishi R., Morishita Y., Kayamuro H., Nabeshi H., Nagano K., Abe Y., Kamada H., Tsunoda S., Yoshikawa T., Itoh N., Tsutsumi Y.
Potential adjuvant effect of intranasal urban aerosols in mice through induction of dendritic cell maturation.
Toxicol. Lett., 199(3):383-388, 2010. [PubMed]
Nabeshi H., Yoshikawa T., Imazawa T., Tsunoda S., Tsutsumi Y.
Safety Asessment of Nanomaterials Using Toxicokinetics and Toxicoproteome Analysis.
Yakugaku Zasshi., 130(4):465-470, 2010. [PubMed]
Nagano K., Imai S., Nakagawa S., Tsunoda S., Tsutsumi Y.
From disease proteomics to biomarker development -Establishment of antibody proteomics technology and exploration of cancer-related biomarkers-
Yakugaku Zasshi., 130(4):487-492, 2010. [PubMed]
Kayamuro H., Yoshioka Y., Abe Y., Katayama K., Hiroi T., Tsunoda S., Tsutsumi Y.
Application of bioactive mutant TNF alpha to a mucosal vaccine adjuvant.
Yakugaku Zasshi., 130(1):55-61, 2010. [PubMed]
Nomura T., Abe Y., Yoshioka Y., Nakagawa S., Tsunoda S., Tsutsumi Y.
Creation of TNFR1-selective antagonist, and its therapeutic effects.
Yakugaku Zasshi., 130(1):63-68, 2010. [PubMed]
Yamashita T., Utoguchi N., Suzuki R., Nagano K., Tunoda S., Tsutsumi Y., Maruyama K.
Development of anti-tumor blood vessel antibodies by phage display method.
Yakugaku Zasshi., 130(4):479-485, 2010. [PubMed]
Yoshioka Y., Yoshikawa T., Tsutsumi Y.
Nano-safety science for assuring the safety of nanomaterials.
Nippon Eiseigaku Zassh., 65(4):487-492, 2010. [PubMed]
2009
Mukai Y., Shibata H., Nakamura T., Yoshioka Y., Abe Y., Nomura T., Taniai M., Ohta T., Ikemizu S., Nakagawa S., Tsunoda S., Kamada H., Yamagata Y., Tsutsumi Y. Structure-function relationship of tumor necrosis factor (TNF) and its receptor interaction based on 3D structural analysis of a fully active TNFR1-selective TNF mutant.
J. Mol. Biol., 385:1221–1229, 2009. [PubMed]
Imai S., Yoshida Y., Okamura T., Nagano K., Abe Y., Yoshikawa T., Kamada H., Nakagawa S., Tsunoda S., Tsutsumi Y.
The specific effect of 2-Methoxyestradiol on lymphatic vascular endothelial cells.
Pharmazie., 64(3):214-6, 2009. [PubMed]
Nagano K., Imai S., Mukai Y., Nakagawa S., Abe Y., Kamada H., Tsunoda S., Tsutsumi Y.
Rapid isolation of intrabody candidates by using an optimized non-immune phage antibody library.
Pharmazie., 64(4):238-41, 2009. [PubMed]
Mukai Y., Nakamura T., Yoshioka Y., Tsunoda S., Kamada H., Nakagawa S., Yamagata Y., Tsutsumi Y.
Crystallization and preliminary X-ray analysis of TNF-TNFR2 complex.
Acta. Crystallogr. Sect. F., 65(Pt 3):295-8, 2009. [PubMed]
Nishimori H., Kondoh M., Isoda K., Tsunoda S., Tsutsumi Y., Yagi K.
Silica nanoparticles as hepatotoxicants.
Eur. J. Pharm. Biopharm., 72(3):496-501, 2009. [PubMed]
Nishimori H., Kondoh M., Isoda K., Tsunoda S., Tsutsumi Y., Yagi K.
Influence of 70-nm silica particles in mice with cisplatin or paraquat-induced toxicity.
Pharmazie., 64(6):395-7, 2009.[PubMed]
Yoshikawa T., Sugita T., Mukai Y., Yamanada N., Nagano K., Nabeshi H., Shibata H., Yoshioka Y., Nakagawa S., Kamada H., Tsunoda S., Tsutsumi Y.
The augmentation of intracellular delivery of peptide therapeutics by artificial protein transduction domains.
Biomaterials., 30(19):3318-23, 2009.[PubMed]
Mukai Y., Nakamura T., Yoshioka Y., Shibata H., Abe Y., Nomura T., Taniai M., Ohta T., Nakagawa S., Tsunoda S., Kamada H., Yamagata Y., Tsutsumi Y.
Fast binding kinetics and conserved 3D structure underlie the antagonistic activity of mutant TNF: useful information for designing artificial proteo-antagonists.
J. Biochem., 146(2):167-72, 2009. [PubMed]
Nishimori H., Kondoh M., Isoda K., Tsunoda S., Tsutsumi Y., Yagi K.
Histological analysis of 70-nm silica particles-induced chronic toxicity in mice.
Eur. J. Pharm. Biopharm., 72(3):626-9, 2009..[PubMed]
Kayamuro H., Yoshioka Y., Abe Y., Katayama K., Yoshida T., Yamashita K., Yoshikawa T., Hiroi T., Itoh N., Kawai Y., Mayumi T., Kamada H., Tsunoda S., Tsutsumi Y.
TNF superfamily member, TL1A, is a potential mucosal vaccine adjuvant.
Biochem. Biophys. Res. Commun., 384(3):296-300, 2009. [PubMed]
Nabeshi H., Yoshikawa T., Kamada H., Shibata H., Sugita T., Abe Y., Nagano K., Nomura T., Minowa K., Tsunoda S., Tsutsumi Y.
Arsenic trioxide has the inhibitory effect on transmission of human T-cell leukemia virus type 1.
Biol. Pharm. Bull., 32(7):1286-8, 2009. [PubMed]
Kayamuro H., Abe Y., Yoshioka Y., Katayama K., Yoshida T., Yamashita K., Yoshikawa T., Hiroi T., Itoh N., Kawai Y., Kamada H., Nagano K., Tsunoda S., Tsutsumi Y.
The use of a mutant TNF-alpha as a vaccine adjuvant for the induction of mucosal immune responses.
Biomaterials., 30(29):5869-5876, 2009. [PubMed]
Nomura T., Abe Y., Kamada H., Inoue M., Kawara T., Arita S., Furuya T., Yoshioka Y., Shibata H., Kayamuro H., Yamashita T., Nagano K., Yoshikawa T., Mukai Y., Nakagawa S., Taniai M., Ohta T., Tsunoda S., Tsutsumi Y.
Novel protein engineering strategy for creating highly receptor-selective mutant TNFs.
Biochem. Biophys. Res. Commun., 30;388(4):667-71, 2009. [PubMed]
Shibata H., Yoshioka Y., Abe Y., Ohkawa A., Nomura T., Minowa K., Mukai Y., Nakagawa S., Taniai M., Ohta T., Tsunoda S., Kamada H., Tsutsumi Y.
The treatment of established murine collagen-induced arthritis with a TNFR1-selective antagonistic mutant TNF.
Biomaterials., 30(34):6638-6647, 2009. [PubMed]
Saeki R., Kondoh M., Kakutani H., Tsunoda S., Mochizuki Y., Hamakubo T., Tsutsumi Y., Horiguchi Y., Yagi K.
A novel tumor-targeted therapy using a claudin-4-targeting molecule.
Mol. Pharmacol., 76(4):918-926, 2009. [PubMed]
Morishige T., Yoshioka Y., Inakura H., Watanabe H., Yao X., Tsunoda S., Tsutsumi Y., Mukai Y., Okada N., Nakagawa S.
LIGHT protein suppresses tumor growth by augmentation of immune response.
Immunol. Lett., 127(1):33-38, 2009. [PubMed]
Kamada H., Fugmann T., Neri D., Roesli C.
Improved protein sequence coverage by on resin deglycosylation and cysteine modification for biomarker discovery.
Proteomics., 9(3):783-787, 2009. [PubMed]
Abe Y., Tsunoda S., Tsutsumi Y.
PEGylated tumor necrosis factor-alpha and its muteins.
Biodrug Delivery Systems: Fundamentals, Applications and Clinical Development., Chapter 28, Informa Healthcare, NY, USA, 2009.
2008
Shibata H., Yoshioka Y., Ohkawa A., Minowa K., Mukai Y., Abe Y., Taniai M., Nomura T., Kayamuro H., Nabeshi H., Sugita T., Imai S., Nagano K., Yoshikawa T., Fujita T., Nakagawa S., Yamamoto A., Ohta T., Hayakawa T., Mayumi T., Vandeenabeele P., Aggarwal BB., Nakamura T., Yamagata Y., Tsunoda S., Kamada H., Tsutsumi Y.
Creation and X-ray structure analysis of the tumor necrosis factor receptor-1-selective mutant of a tumor necrosis factor-alpha antagonist.
J. Biol. Chem., 283:998-1007, 2008. [PubMed]
Sugita T., Yoshikawa T., Mukai Y., Yamanada N., Imai S., Nagano K., Yoshida Y., Shibata H., Yoshioka Y., Nakagawa S., Kamada H., Tsunoda S., Tsutsumi Y.
Comparative Study of the Protein Transduction Domains-Mediated Molecular Transduction.
Br. J. Pharmacol., 153(6):1143-52, 2008. [PubMed]
Abe Y., Yoshikawa T., Kamada H., Shibata H., Nomura T., Minowa K., Kayamuro H., Katayama K., Miyoshi H., Mukai Y., Yoshioka Y., Nakagawa S., Tsunoda S., Tsutsumi Y.
Simple and highly sensitive assay system for TNFR2-mediated soluble- and transmembrane-TNF activity.
J. Immunol. Methods., 335(1-2):71-8, 2008. [PubMed]
Yoshikawa T., Sugita T., Mukai Y., Yamanada N., Nagano K., Nabeshi H., Yoshioka Y., Nakagawa S., Abe Y., Kamada H., Tsunoda S., Tsutsumi Y.
Organelle-targeted delivery of biological macromolecules using the protein transduction domain: Potential applications for peptide aptamer delivery into the nucleus.
J. Mol. Biol., 380(5):777-782, 2008. [PubMed]
Yoshikawa M., Mukai Y., Okada Y., Yoshioka Y., Tsunoda S., Tsutsumi Y., Okada N., Doi T., Nakagawa S.
Ligand independent assembly of purified soluble human Magic Roundabout (Robo4), a tumor endotherial specific marker.
Protein. Expr. Purif., 61(1):78-82, 2008. [PubMed]
Gao J.Q., Kanagawa N., Xu D.H., Han M., Sugita T., Hatanaka Y., Tani Y., Mizuguchi H., Tsutsumi Y., Mayumi T., Okada N., Nakagawa S.
Combination of two fiber-mutant adenovirus vectors, one encoding the chemokine FKN and another encoding cytokine interleukin 12, elicits notably enhanced anti-tumor responses.
Cancer. Immunol. Immunother., 58:291-299, 2008. [PubMed]
Imai S., Mukai Y., Takeda T., Abe Y., Nagano K., Kamada H., Nakagawa S., Tsunoda S., Tsutsumi Y.
The effect of protein properties on display efficiency using the M13 phage display system.
Pharmazie., 63(10):760-764, 2008. [PubMed]
Shibata H., Yoshioka Y., Ohkawa A., Abe Y., Nomura T., Mukai Y., Nakagawa S., Taniai M., Ohta T., Mayumi T., Kamada H., Tsutsumi Y.
The therapeutic effect of TNFR1-selective antagonistic mutant TNF-α in murine hepatitis models.
Cytokine., 44(2):229-233, 2008. [PubMed]
Takahashi A., Komiya E., Kakutani H., Yoshida T., Fujii M., Horiguchi Y., Mizuguchi H., Tsutsumi Y., Tsunoda S., Koizumi N., Isoda K., Yagi K., Watanabe Y., Kondoh M.
Domain mapping of a claudin-4 modulator, the C-terminal region of C-terminal fragment of clostridium perfringens enterotoxin, by site-directed mutagenesis.
Biochem. Pharm., 75:1639-1648, 2008. [PubMed]
Yoshikawa T., Nabeshi H., Yoshioka Y.
Evaluation of Biological Influence of Nano-materials using Toxicokinetic and Toxicoproteomic Approach.
Yakugaku Zasshi., 128(12):1715-1725, 2008. [PubMed]
Tsunoda S., Tsutsumi Y.
Application of nanomaterials for drug innovation and their risks.
Yakugaku Zasshi., 128(12):1713-1714, 2008. [PubMed]